ALK and NSCLC: Targeted therapy with ALK inhibitors - F1000 ...
Nov 1, 2011 . ALK and NSCLC: Targeted therapy with ALK inhibitors. . basic pathology behind NSCLC at the molecular level has offered up a host of new molecularly targeted therapies, which are revolutionizing this area of cancer care.
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NFCR Center for Targeted Cancer Therapies . Center first demonstrated that pancreatic cancer cells produce an abnormally large amount of uPA, a protein that .
Targeted therapies in cancer - challenges and chances offered by ...
Targeted therapies in cancer - challenges and chances offered by newly . (uPA), plasminogen activator inhibitor 1 (PAI-1), personalized cancer therapy, .
Promising molecular targeted therapies in breast cancer
Keywords: Breast cancer, chemotherapy, targeted therapy . The serine protease uPA (urokinase-type plasminogen activator) and its receptor uPAR ( CD87) .
TARGETING YOUR LUNG CANCER: PERSONALIZED MEDICINE ...
works for one patient with lung cancer may not work for another. . not all mutations at the present time have effective targeted therapies . in the body has the same library of genes that act as the blueprints for everything else that makes up a .
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Five Key Insights from the Targeted Therapies in Lung Cancer ...
Feb 25, 2012 . But the cancers developing in longtime smokers, even with . Having read up a lot on targeted treatments it looks like the more we learn the .
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Targeted Alpha Therapy Approach to the Management of Pancreatic ...
That uPA and its receptor uPAR can act as a target for anti-cancer therapy has been extensively documented in mouse models [30,31]. Bound to its specific cell .
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Optimizing Molecular-Targeted Therapies in Ovarian Cancer: The ...
Biomarker †, Molecular basis for biomarker targeting in ovarian cancer, References . apoptosis in ovarian cancer cells; BIK also downregulates uPA/R and HBP .
The chance discovery that could revolutionise lung cancer treatment ...
Nov 7, 2011 . Targeted gene therapies are the future of treatment, not just for cancer but many other illnesses. While many disorders such as heart disease, .
Targeted therapy - Wikipedia, the free encyclopedia
Targeted therapy is a type of medication that blocks the growth of cancer cells by . Targeted cancer therapies may be more effective than current treatments and .
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When "personalized gene-targeted cancer therapy" really means ...
Dec 5, 2011 . In fact, the idea of targeted therapy in cancer is not new. . For purposes of the study, they set up a special tumor board to evaluate their .
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Targeted Therapy in Breast Cancer
Targeted Therapy in Breast Cancer . the response of breast cancer to other therapies including hormonal therapies . protease (uPA, PAI-1) levels were both .
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Molecularly targeted therapy and cancer surgery
Molecularly targeted therapy and cancer surgery. I. Judson and J. . treatment for most cancers. With . opens up a new area of clinical study. It may be that the .
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About Pancreatic Cancer: Causes, Risk Factors, Symptoms ...
Learn more about pancreatic cancer pain relief and how to improve the quality of one's remaining life. The Development of uPA Targeted Therapy for Cancer .
Targeted Therapies in Oncology - ERADIMAGING.COM: CE, FIND ...
May 21, 2011 . The original targeted therapy was radioiodine for thyroid cancer which had . daunorubicin) to make up a nuclisome or a PEGylated liposome.
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Can Immune Therapy Fight Cancer? : The New Yorker
Apr 23, 2012 . In the last hundred years, progress in the treatment of cancer has come mostly . that cancer was caused by a virus that speeded up a cell's metabolism, . The first successful targeted therapy was Gleevec, which caused rapid .
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Targeted Therapies for the Treatment of Metastatic Renal Cell ...
Molecular-targeted therapies have better efficacy and tolerability than cytokine . trials, given the inherent complications of a required long duration of follow-up, a . was assessed with the Functional Assessment of Cancer Therapy–General .
Abstract - Molecular Cancer Therapeutics - AACR Publications
Taken together, these data indicate that uPA-activated toxins may be promising candidates for targeted therapy of human cancers that overexpress uPA and its .
Uterine Cancer | Cancer.Net
Feb 9, 2012 . Women who have had previous radiation therapy in the pelvic area (the . Types of targeted therapy being studied for uterine cancer include .
2012-01 - Targeted Therapies and Personalized Medicine - Living ...
January 2012 Ask the Expert: Targeted Therapies and Personalized Medicine . Hormonal therapy or HER2-targeted therapy can target these cancer cells, . brings up a few issues surrounding alcohol use and its relationship to breast cancer .
Combinations of Targeted Therapies Take Aim at Multiple Pathways
Journal of the National Cancer Institute, Vol. 95, No. 22, November 19 . therapy —are raising hopes that cancer . up a trial combining two targeted therapies .
Targeted therapies in cancer - challenges and chances offered by ...
Dec 19, 2010 . Targeted therapies in cancer - challenges and chances offered by newly . Urokinase-type plasminogen activator (uPA) and its inhibitor .
Clinical Response of Metastatic Breast Cancer to Multi-targeted ...
On the other hand, a plethora of “alternative” cancer therapies have been . cancer, and UPA inhibition has therefore been made the target of extensive .
Drugs in preclinical and early-stage clinical development for ...
An antibody known as ATN-658 is currently in preclinical development for uPA- targeted therapy for cancer. Further ongoing research work on the peptide .
Targeted Therapy for Malignant Glioma Patients: Lessons Learned ...
molecular circuitry of cancer cells, such as loss of key tumor suppressor proteins . proaches toward targeted therapy, and describe how a deeper understanding of . activated in malignant gliomas has opened up a range of other possibilities .
Patient Resource Publishing : Tumor Biomarkers
Protein biomarkers include substances that are either produced by cancer cells themselves or . of gene is associated with response to specific targeted therapy. . uPA (urokinase-type plasminogen activator), PAI-1, Tumor tissue, Determine .
Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 ...
to novel therapeutic agents targeted against the uPA/uPA-R system (29). In metastatic breast cancer, retrospective studies have suggested that high uPA or .
Targeted Molecular Therapy in Head and Neck Squamous Cell ...
Mar 29, 2011 . The goal of specific molecular targets in cancer therapy is to create a “magic bullet” . Targeted molecular therapy, like therapy with monoclonal . The use of anti-uPA antibodies has been shown to prevent tumor invasion in .
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Bone Cancer Overview
Jan 16, 2012 . Cancers that start in the bones (primary bone cancers) make up a very small . is a targeted therapy drug that can block the signals from .
Figure 1 : Bone metastasis in prostate cancer: emerging therapeutic ...
Therapeutic approaches to target the osteolytic and osteosclerotic microenvironment of MBD in prostate cancer include bisphosphonates, radionuclides and .
Istituto di Ricerca e Cura del Cancro di Candiolo
These oncologists realised that the system of cancer care was inefficient and it was necessary to set up a centre of excellence to integrate research and clinical practice. . The IRCC's strategy is to develop the field of targeted therapies by: (i) .
Targeted -therapy for control of micrometastatic prostate cancer
aggressive therapies, the control of metastatic prostate cancer remains an elusive objective and . uPA-targeted therapy will appreciably affect normal tissues.
The Birth of a Targeted Therapy - Cancer Today
Dec 5, 2011 . The Birth of a Targeted Therapy. A serendiptious discovery more than 50 years ago heralded a new age of cancer treatment. By Jocelyn Selim .
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Circulating tumor cells in breast cancer: Advanced tools for “tailored ...
Nov 14, 2006 . The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe . cells ( CTCs) for personalizing targeted therapy of cancer in the future. . and urokinase plasminogen activator (uPA)] or the truncated form of the .
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Apr 23, 2012 . The very term cancer used to evoke fear, due to the high possibility . Further genetic-targeted therapy has restricted the continuous growing of cancer cells. . including tie up with oncologists to setting up a full-fledged centre.
More Research Needed to Define Appropriate Targets for Biologic ...
Mar 30, 2012 . Intelligent use of targeted therapies in gastric cancer is an important goal but . “ These authors were setting up a dichotomy,” Shah explained.
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