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  • ALK and NSCLC: Targeted therapy with ALK inhibitors - F1000 ...
    Nov 1, 2011 . ALK and NSCLC: Targeted therapy with ALK inhibitors. . basic pathology behind NSCLC at the molecular level has offered up a host of new molecularly targeted therapies, which are revolutionizing this area of cancer care.
    http://f1000.com/reports/m/3/21/

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    Pancreatic Cancer
    NFCR Center for Targeted Cancer Therapies . Center first demonstrated that pancreatic cancer cells produce an abnormally large amount of uPA, a protein that .
    http://www.nfcr.org/index.php/pancreatic-cancer


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    Targeted therapies in cancer - challenges and chances offered by ...
    Targeted therapies in cancer - challenges and chances offered by newly . (uPA), plasminogen activator inhibitor 1 (PAI-1), personalized cancer therapy, .
    http://www.jcancer.org/v02p0026.htm



    Promising molecular targeted therapies in breast cancer
    Keywords: Breast cancer, chemotherapy, targeted therapy . The serine protease uPA (urokinase-type plasminogen activator) and its receptor uPAR ( CD87) .
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113372/


    TARGETING YOUR LUNG CANCER: PERSONALIZED MEDICINE ...
    works for one patient with lung cancer may not work for another. . not all mutations at the present time have effective targeted therapies . in the body has the same library of genes that act as the blueprints for everything else that makes up a .
    http://www.lcfamerica.org/downloads/lcfa_targeting_poster.pdf

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    Five Key Insights from the Targeted Therapies in Lung Cancer ...
    Feb 25, 2012 . But the cancers developing in longtime smokers, even with . Having read up a lot on targeted treatments it looks like the more we learn the .
    http://cancergrace.org/lung/2012/02/25/5takeawaystargetedrx/


     

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    Targeted Alpha Therapy Approach to the Management of Pancreatic ...
    That uPA and its receptor uPAR can act as a target for anti-cancer therapy has been extensively documented in mouse models [30,31]. Bound to its specific cell .
    http://www.mdpi.com/2072-6694/3/2/1821/pdf

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    Optimizing Molecular-Targeted Therapies in Ovarian Cancer: The ...
    Biomarker †, Molecular basis for biomarker targeting in ovarian cancer, References . apoptosis in ovarian cancer cells; BIK also downregulates uPA/R and HBP .
    http://www.hindawi.com/journals/jo/2012/737981/tab1/

    The chance discovery that could revolutionise lung cancer treatment ...
    Nov 7, 2011 . Targeted gene therapies are the future of treatment, not just for cancer but many other illnesses. While many disorders such as heart disease, .
    http://www.telegraph.co.uk/health/healthnews/8869823/The-chance-discovery-that-could-revolutionise-lung-cancer-treatment.html


    Targeted therapy - Wikipedia, the free encyclopedia
    Targeted therapy is a type of medication that blocks the growth of cancer cells by . Targeted cancer therapies may be more effective than current treatments and .
    http://en.wikipedia.org/wiki/Targeted_therapy

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    When "personalized gene-targeted cancer therapy" really means ...
    Dec 5, 2011 . In fact, the idea of targeted therapy in cancer is not new. . For purposes of the study, they set up a special tumor board to evaluate their .
    http://scienceblogs.com/insolence/2011/12/personalized_gene-targeted_cancer_therapy.php

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    Targeted Therapy in Breast Cancer
    Targeted Therapy in Breast Cancer . the response of breast cancer to other therapies including hormonal therapies . protease (uPA, PAI-1) levels were both .
    http://www.mcponline.org/content/3/4/379.full.pdf

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    Molecularly targeted therapy and cancer surgery
    Molecularly targeted therapy and cancer surgery. I. Judson and J. . treatment for most cancers. With . opens up a new area of clinical study. It may be that the .
    http://onlinelibrary.wiley.com/doi/10.1002/bjs.6176/pdf

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    About Pancreatic Cancer: Causes, Risk Factors, Symptoms ...
    Learn more about pancreatic cancer pain relief and how to improve the quality of one's remaining life. The Development of uPA Targeted Therapy for Cancer .
    http://www.healthguideinfo.com/pancreatic-cancer/


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    Targeted Therapies in Oncology - ERADIMAGING.COM: CE, FIND ...
    May 21, 2011 . The original targeted therapy was radioiodine for thyroid cancer which had . daunorubicin) to make up a nuclisome or a PEGylated liposome.
    http://www.eradimaging.com/site/article.cfm?ID=765


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    Can Immune Therapy Fight Cancer? : The New Yorker
    Apr 23, 2012 . In the last hundred years, progress in the treatment of cancer has come mostly . that cancer was caused by a virus that speeded up a cell's metabolism, . The first successful targeted therapy was Gleevec, which caused rapid .
    http://www.newyorker.com/reporting/2012/04/23/120423fa_fact_groopman

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    Targeted Therapies for the Treatment of Metastatic Renal Cell ...
    Molecular-targeted therapies have better efficacy and tolerability than cytokine . trials, given the inherent complications of a required long duration of follow-up, a . was assessed with the Functional Assessment of Cancer Therapy–General .
    http://theoncologist.alphamedpress.org/content/16/suppl_2/14.full

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    Abstract - Molecular Cancer Therapeutics - AACR Publications
    Taken together, these data indicate that uPA-activated toxins may be promising candidates for targeted therapy of human cancers that overexpress uPA and its .
    http://mct.aacrjournals.org/content/5/1/89.abstract

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    Uterine Cancer | Cancer.Net
    Feb 9, 2012 . Women who have had previous radiation therapy in the pelvic area (the . Types of targeted therapy being studied for uterine cancer include .
    http://www.cancer.net/patient/Cancer+Types/Uterine+Cancer/ci.Uterine+Cancer.printer

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    2012-01 - Targeted Therapies and Personalized Medicine - Living ...
    January 2012 Ask the Expert: Targeted Therapies and Personalized Medicine . Hormonal therapy or HER2-targeted therapy can target these cancer cells, . brings up a few issues surrounding alcohol use and its relationship to breast cancer .
    http://www.lbbc.org/Learning-From-Others/Ask-the-Expert/2012-01-Targeted-Therapies-and-Personalized-Medicine

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    Combinations of Targeted Therapies Take Aim at Multiple Pathways
    Journal of the National Cancer Institute, Vol. 95, No. 22, November 19 . therapy —are raising hopes that cancer . up a trial combining two targeted therapies .
    http://jnci.oxfordjournals.org/content/95/22/1656.full.pdf

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    Targeted therapies in cancer - challenges and chances offered by ...
    Dec 19, 2010 . Targeted therapies in cancer - challenges and chances offered by newly . Urokinase-type plasminogen activator (uPA) and its inhibitor .
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005552/

    • Clinical Response of Metastatic Breast Cancer to Multi-targeted ...
      On the other hand, a plethora of “alternative” cancer therapies have been . cancer, and UPA inhibition has therefore been made the target of extensive .
      http://www.mdpi.com/2072-6694/3/1/1454/pdf


    • Drugs in preclinical and early-stage clinical development for ...
      An antibody known as ATN-658 is currently in preclinical development for uPA- targeted therapy for cancer. Further ongoing research work on the peptide .
      http://informahealthcare.com/doi/abs/10.1517/13543784.2012.651124

    • Targeted Therapy for Malignant Glioma Patients: Lessons Learned ...
      molecular circuitry of cancer cells, such as loss of key tumor suppressor proteins . proaches toward targeted therapy, and describe how a deeper understanding of . activated in malignant gliomas has opened up a range of other possibilities .
      http://neurooncology.ucla.edu/pub/19560740.pdf

    • Patient Resource Publishing : Tumor Biomarkers
      Protein biomarkers include substances that are either produced by cancer cells themselves or . of gene is associated with response to specific targeted therapy. . uPA (urokinase-type plasminogen activator), PAI-1, Tumor tissue, Determine .
      http://www.patientresource.com/Tumor_Biomarkers.aspx

    • Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 ...
      to novel therapeutic agents targeted against the uPA/uPA-R system (29). In metastatic breast cancer, retrospective studies have suggested that high uPA or .
      http://www.schattauer.de/en/magazine/subject-areas/journals-a-z/thrombosis-and-haemostasis/contents/archive/issue/775/manuscript/3681/download.html

    • Targeted Molecular Therapy in Head and Neck Squamous Cell ...
      Mar 29, 2011 . The goal of specific molecular targets in cancer therapy is to create a “magic bullet” . Targeted molecular therapy, like therapy with monoclonal . The use of anti-uPA antibodies has been shown to prevent tumor invasion in .
      http://emedicine.medscape.com/article/854971-overview

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    Bone Cancer Overview
    Jan 16, 2012 . Cancers that start in the bones (primary bone cancers) make up a very small . is a targeted therapy drug that can block the signals from .
    http://www.cancer.org/acs/groups/cid/documents/webcontent/003034-pdf.pdf

    Figure 1 : Bone metastasis in prostate cancer: emerging therapeutic ...
    Therapeutic approaches to target the osteolytic and osteosclerotic microenvironment of MBD in prostate cancer include bisphosphonates, radionuclides and .
    http://www.nature.com/nrclinonc/journal/v8/n6/fig_tab/nrclinonc.2011.67_F1.html

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    Istituto di Ricerca e Cura del Cancro di Candiolo
    These oncologists realised that the system of cancer care was inefficient and it was necessary to set up a centre of excellence to integrate research and clinical practice. . The IRCC's strategy is to develop the field of targeted therapies by: (i) .
    http://ecancer.org/directory/39

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    Targeted -therapy for control of micrometastatic prostate cancer
    aggressive therapies, the control of metastatic prostate cancer remains an elusive objective and . uPA-targeted therapy will appreciably affect normal tissues.
    http://www.expert-reviews.com/doi/abs/10.1586/14737140.4.3.459

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    The Birth of a Targeted Therapy - Cancer Today
    Dec 5, 2011 . The Birth of a Targeted Therapy. A serendiptious discovery more than 50 years ago heralded a new age of cancer treatment. By Jocelyn Selim .
    http://www.cancertodaymag.org/Winter2011/Pages/targeted-therapy.aspx

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    Circulating tumor cells in breast cancer: Advanced tools for “tailored ...
    Nov 14, 2006 . The University of Texas, M. D. Anderson Cancer Center, 1515 Holcombe . cells ( CTCs) for personalizing targeted therapy of cancer in the future. . and urokinase plasminogen activator (uPA)] or the truncated form of the .
    http://www.pnas.org/content/103/46/17073.full

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    HCG Oncology
    Apr 23, 2012 . The very term cancer used to evoke fear, due to the high possibility . Further genetic-targeted therapy has restricted the continuous growing of cancer cells. . including tie up with oncologists to setting up a full-fledged centre.
    http://www.hcgoncology.com/hcg-blog/

    More Research Needed to Define Appropriate Targets for Biologic ...
    Mar 30, 2012 . Intelligent use of targeted therapies in gastric cancer is an important goal but . “ These authors were setting up a dichotomy,” Shah explained.
    http://www.onclive.com/publications/obtn/2012/March-2012/More-Research-Needed-to-Define-Appropriate-Targets-for-Biologic-Therapy-of-Gastric-Cancer

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