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  • How do drugs work?
    If a drug causes the protein receptor to respond in the same way as the . are drugs that interact selectively with receptors but do not lead to an observed effect. . such as heroin, cocaine and marijuana, act at G-protein-coupled receptors in .
    http://www.edinformatics.com/interactive_molecules/how_drugs_work.htm

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    Chronic Heroin Self-Administration Desensitizes ? Opioid Receptor ...
    Jun 15, 2000. and receptor-activated G-proteins were examined after chronic heroin . No effects on agonist-stimulated [35S]GTP?S binding were found for .
    http://www.jneurosci.org/content/20/12/4555.short


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    Chronic Heroin Self-Administration Desensitizes Opioid Receptor ...
    Key words: opioid receptor; heroin; G-protein; desensitiza- . Effect of chronic heroin self-administration on agonist-stimulated [35S]GTP S binding in rat brain .
    http://www.jneurosci.org/content/20/12/4555.full.pdf



    Chronic heroin self-administration desensitizes mu opioid receptor ...
    Jun 15, 2000. and receptor-activated G-proteins were examined after chronic heroin . No effects on agonist-stimulated [(35)S]GTPgammaS binding were .
    http://www.ncbi.nlm.nih.gov/pubmed/10844025


    Heroin and the plague of walking dead
    Heroin is named after the German word for hero, heroisch. . The effects usually wear off in 3-5 hours, depending on the dose. . Opioid receptors are proteins embedded in the cell membrane; opioid agonists bind to the receptors to initiate .
    http://opioids.com/heroin.html

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    Modulation of Fas receptor proteins and dynamin during opiate ...
    ments with the µ-opioid receptor agonists heroin (10 mg/kg) and morphine (30 mg/kg) . 10047 also decreased native Fas (37%) and the effect was blocked by the ?1 antagonist BD 1063. . for 30 s to 2 min (autoradiograms). Quantitation of .
    http://www.springerlink.com/index/C8KVHMJ0QLLMPDFG.pdf


     

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    Narcotic Drugs - symptoms, Definition, Description, General use ...
    Partially synthetic drugs derived from morphine: These drugs include heroin, oxycodone . When a narcotic medication stimulates these receptor proteins, the person . The speed with which these drugs take effect depends on the method of .
    http://www.healthofchildren.com/N-O/Narcotic-Drugs.html

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    recreational drugs: Information from Answers.com
    People take recreational drugs because they find their effects on the brain pleasurable . Thus, heroin is recognized in the brain by specific receptor proteins that .
    http://www.answers.com/topic/recreational-drugs

    Pharmacokinetics and Pharmacokinetic Variability of Heroin and its ...
    glucuronidation of morphine and interactions with drug transporting proteins are . effect with a more immediate onset of heroin compared to morphine. However, opioid receptors are stereo-specific and heroin shows a lower opioid receptor affinity than its . Klemenc S. 4-Dimethylaminopyridine as a catalyst in heroin .
    http://benthamscience.com/ccp/samples/ccp1-1/Rook.pdf


    Morphine & Heroin
    This eliminates the action of the pain receptor, preventing the pain signals reaching . of the morphine molecule fits snugly against a flat section of the receptor protein, . Morphine blocks deep aching pain, but has no effect on the fast pain that .
    http://www.ch.ic.ac.uk/rzepa/mim/drugs/html/morphine_text.htm

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    kappa Opioid receptor - Wikipedia, the free encyclopedia
    activation of phospholipase C activity by G-protein coupled receptor protein signaling . These effects include altering the perception of pain, consciousness, motor . in self-administration of alcohol, and heroin dependence has also been shown to . a b Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, .
    http://en.wikipedia.org/wiki/Kappa_Opioid_receptor

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    Neurotransmitters and Learning, Memory and Developmental ...
    Neurotransmitters travel across a synapse to bind to a postsynaptic receptor protein; . Exorphins include heroin, peptides from digestion of food protein, and the . To have any effect on behavior, the neurotransmitter must be released from the .
    http://www.childrensdisabilities.info/allergies/developmentaldisorderslearningmemory2.html

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    Effect of -Opioid Receptor Gene Polymorphisms on Heroin-Induced ...
    receptor is the molecular target of heroin mediating its effects in both pain relief and euphoria. . ning G protein-coupled receptors that are of fundamental phys- . Beyer A, Koch T, Schroder H, Schulz S, Hollt V (2004): Effect of the A118G .
    http://humpopgenfudan.cn/p/F/F13.pdf

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    Drugs and the Nervous System
    Postsynaptic neurons display receptors to which the neurotransmitter binds. . Its popularity comes not from its sedative effect but from the sense of well-being that . Although heroin is even more effective as a painkiller than morphine and codeine, it is so . These G-protein-coupled receptors are located on the subsynaptic .
    http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/D/Drugs.html


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    Alcohol Dependancy, The Neurobiology of Addiction, Clinical Aspects
    All addictive substances impact dopamine directly or indirectly. . Stimulation of the opiate receptor by heroin or alcohol-induced endorphins causes cells to . Dopamine receptors belong to a family of protein receptors expressed on the .
    http://www.alcoholmd.com/dependancy.htm


    The easiest way we've found is to dig up the clump, shake off a the soil, lay the clump on its side and gently pry off pieces using a weeding fork as illustrated raised beds for foundation planting.

    Differential regional effects of methadone maintenance compared to ...
    differences between the effects of heroin and methadone. Rats were trained to self- . tenance on m-opioid receptor activation of G-proteins may be quite different . ent, loss of consciousness occurred within 1–2 s and lasted less than 5 min.
    http://onlinelibrary.wiley.com/doi/10.1002/syn.20355/pdf

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    Addicted brains : the chemistry of pain and pleasure
    These adaptations, perversely, dampen the pleasurable effects of a chronically . cocaine, heroin, amphetamine and many other common habit-forming drugs. . by the shuttling of certain glutamate-binding receptor proteins from intracellular .
    http://wireheading.com/article/addiction.html

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    Reward Processing by the Opioid System in the Brain
    Heroin was synthesized chemically by morphine diacetylation in the late 1800s and was . Top panel represents the distribution of opioid receptor proteins as . In contrast, when injected into the VP, naloxone failed to affect the increased food . Craving for drug(s) persists over years after the cessation of drug taking and .
    http://physrev.physiology.org/content/89/4/1379.full

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    Dopamine's effect on opioids
    Since each class of receptor has a unique effect on the cell, the multitude of classes . Cloning demonstrates that the receptors are usually G protein-linked . A key study found that heroine self-administration continues after disruption of DA .
    http://www.macalester.edu/psychology/whathap/UBNRP/Dopamine/opioids.html

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    Mu Opioid Receptor Regulation And Opiate Responsiveness
    The opioid receptors belong to the family of G protein-coupled receptors (GPCRs ), and . and heroin do not promote robust ?arrestin2 translocation or receptor . Effects of chronic morphine administration on mu opioid receptor-stimulated . Imamura T, Huang J, Dalle S, et al. beta -Arrestin-mediated recruitment of the Src .
    http://www.aapsj.org/view.asp?art=aapsj070360

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    Apoptosis may involve in prenatally heroin exposed ... - ScienceDirect
    Heroin abuse during pregnancy is a serious problem worldwide. Among all . Your selection(s) could not be saved due to an internal error. . and receptors of which dopamine is the most commonly affected neurotransmitter. . Modulation of Fas receptor proteins and dynamin during opiate addiction and induction of opiate .
    http://www.sciencedirect.com/science/article/pii/S0306987709004290

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    Heroin neuroteratogenicity: targeting adenylyl cyclase as an ...
    Keywords: Adenylyl cyclase; G-Protein; Heroin; Opiate . target signaling proteins that are shared by multiple types of receptor and hormonal inputs. . However, the effects on the response to NaF, which activates both Gs and inhibitory (Gi) .
    http://linkinghub.elsevier.com/retrieve/pii/S0165380601002966

    • 3-D structure of brain's 'pleasure molecules' could help combat ...
      Mar 22, 2012 . They said that unravelling of the structure of the opiod receptors on . drugs such as morphine, codeine and heroin—as well as opium. . Even the psychedelic effect associated with the activation of the kappa receptor protein .
      http://www.dnaindia.com/scitech/report_3-d-structure-of-brain-s-pleasure-molecules-could-help-combat-depression_1665987


    • Prenatal Cannabis Exposure Increases Heroin Seeking with ...
      Methods: We used an animal model to study the effects of prenatal exposure to 9- tetrahydrocannabinol (THC) on heroin . tion, S-17176 Stockholm, Sweden. Address reprint requests to . CB1 and Opioid Receptor G-protein Coupling .
      http://people.usd.edu/~cliff/Courses/Advanced%20Seminars%20in%20Neuroendocrinology/Stress%20and%20Drugs%20of%20Abuse/Spano07.pdf

    • Marijuana and the Brain
      But the discovery of THC receptor sites in the brain refutes that thinking, and may force . similar to the dangerously addictive effects of opiates such as morphine and heroin. . Receptors are actually proteins in neurons which are specific to .
      http://druglibrary.org/schaffer/hemp/BRAIN.HTM

    • What does wheat have in common with heroin and morphine?
      Aug 3, 2011 . When wheat gluten proteins are broken down in the digestive tract, they form peptides that activate opioid receptors, just like heroin and morphine. . receptors ”, which are receptors in the body and brain that are affected by . in some country, it;'s unbelievable that it can compare to heroin and morphine.
      http://www.kriskris.com/wheat-heroin-morphine/

    • Molecular mechanisms of opioid receptor signal transduction
      heroin, a compound initially hailed as a safer and less addictive option . tors opioid, G-protein-coupled; receptors opioid, internaliza- tion; receptors . long- term effect of agonists on the molecular mecha- nisms of signal . Biological effects of receptor activation . Chakrabarti S, Prather P, Yu L, Law P, Loh H. Expression of .
      http://bja.oxfordjournals.org/content/81/1/12.full.pdf

    • How Drugs Affect The Brain - Addictions: Alcohol and Substance ...
      Learn about the basic mechanisms by which drugs and alcohol affect the . connect in lock-and-key fashion with protein structures known as 'receptors' . including Cocaine, Amphetamine, opiates, marijuana, heroin and PCP . actually i smoked onece in my life and it was the number one mistake i ever commit but it,s also .
      http://www.centersite.net/poc/view_doc.php?type=doc&id=1059&cn=14

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    Microinjection of M(5) muscarinic receptor antisense oligonucleotide ...
    OBJECTIVE: To investigate the effect of M(5) muscarinic receptor subtype on the locomotor sensitization induced by heroin priming, and it's effect on the FosB . microinjection of M(5) muscarinic receptor sense oligonucleotide (S-ONs) into the . Proteins c-fos/drug effects; Proto-Oncogene Proteins c-fos/metabolism*; Rats .
    http://www.ncbi.nlm.nih.gov/pubmed/17592519

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    B R S S
    the brain's own opiates and opiate receptors, specialized proteins located on the . causes a weaker effect on the receptors than methadone and heroin, and creates . S. TO. R. IES. Continued funding for research could lead to: • Improved .
    http://www.sfn.org/skins/main/pdf/brss/BRSS_opiateAddiction.pdf

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    Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review
    Effect of pharmacological manipulations on heroin- or cocaine . of the D1- and D2-like receptors by using an activator (SP-cAMPS) and an inhibitor (RP-cAMPS) of protein . (2000) reported that priming cocaine injections increase Fos protein .
    http://pharmrev.aspetjournals.org/content/54/1/1.full

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    Heroin - Drugs Forum
    The onset of the effects of heroin is dependent on route of administration determined . GABA proteins are involved in the release and inhibition of dopamine. . When the morphine binds to the opiate receptor on the GABA neuron it represses .
    http://www.drugs-forum.com/forum/showwiki.php?title=Heroin

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    Heroin - Wikipedia, the free encyclopedia
    Protein binding, 0% (morphine metabolite 35%) . This reverses the effects of heroin and other opioid agonists and causes an immediate return of . anxiolytic ( anti-anxiety) effects; heroin itself exhibits relatively low affinity for the ? receptor.
    http://en.wikipedia.org/wiki/Heroin

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    Opioid Abuse
    Feb 29, 2012 . Semi-synthetic opioids include heroin, oxycodone, oxymorphone, and hydrocodone. . The pain relieving and euphoric effects of opioids were known to . Most of these are prototypical mu receptor full agonists (capable of producing a maximal . Down-regulated second messengers include G-proteins and .
    http://emedicine.medscape.com/article/287790-overview

    Heroin: The Junk Equation
    Discusses the actions and effects of heroin and other narcotics, and outlines critical factors in . William S. Burroughs, Junkie . chemical transmitters and receptors virtually identical to heroin and other narcotics. . In short, the reason that heroin works in the body is because it so closely resembles bits of protein in the brain .
    http://www.doitnow.org/pages/105.html

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